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Quite a few research studies on ganoderma extracts have been done at universities in Japan, China, and South Korea. Many of these are test-tube or animal studies. The results are not clear-cut, but they seem to indicate that at least in these non-human systems, ganoderma has an effect on the immune system, some anti-tumor properties, and some anti-viral activity.
Ganoderma is also used in treating conditions of the nervous system. It is used to calm the nerves, cure insomnia, reduce stress, eliminate nervous exhaustion, and increase determination and focus. Laboratory studies show fairly conclusively that ganoderma does act as a sedative on cells of the central nervous system and possibly has painkilling and anti-convulsive properties.
Ganoderma is frequently used to treat allergies, hay fever, bronchial asthma, and to reduce skin inflammation. Laboratory studies support these uses and show that some components of ganoderma have a strong antihistamine effect that interrupts the development of allergic reactions.